It depends on what you're talking about. The first amendment has exceptions as does every other amendment to the Constitution. While it may be up for debate as t o the Constitutionality however most people seem to agree with the Supreme Court's decisions. Take for example freedom of speech. Freedom of speech is okay unless that speech is harmful. For example CP, fraud, blackmail, perjury, obscenity, defamation (including libel and slander), fighting words, true threats, incitement to imminent lawless action, solicitations to commit crimes, etc. Freedom of the press is okay unless your confidential source violated federal law in exposing government corruption. Then a judge could subpoena you and force you to name names. Same with libel, incitement, obscenity or fighting words. None of that is allowed in the press either. Or freedom of religion. The free exercise thereof has always been a point of contention in the Supreme Court. A few examples would be if you're say an indigenous American and use peyote in religious ceremonies. You can still be prosecuted or fired from your job. Or if you discriminate against gays in housing, employment or other services. Or if you're a Seventh Day Adventist and don't work on Saturdays. Or if a religious institution doesn't want to pay for contraceptives. Or if your church doesn't allow gay weddings.
Same goes with the right to peaceable assembly and the right to petition the goernment for a redress of grievances. The government can impose restrictions on the time, place, and manner of peaceful assembly, require a permit, the government can also make special regulations that impose additional requirements for assemblies that take place near major public events and they can deny your permit if there's a risk of a riot, disorder or interference with traffic on public streets. Also, lobbying, right to file suits, certain kinds of libel actions involving government officials and SLAPP suits aren't protected either.